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Genomic identification and characterization of the pseudoautosomal region in highly differentiated avian sex chromosomes
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
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2014 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 5, 5448- p.Article in journal (Refereed) Published
Abstract [en]

The molecular characteristics of the pseudoautosomal region (PAR) of sex chromosomes remain elusive. Despite significant genome-sequencing efforts, the PAR of highly differentiated avian sex chromosomes remains to be identified. Here we use linkage analysis together with whole-genome re-sequencing to uncover the 630-kb PAR of an ecological model species, the collared flycatcher. The PAR contains 22 protein-coding genes and is GC rich. The genetic length is 64cM in female meiosis, consistent with an obligate crossing-over event. Recombination is concentrated to a hotspot region, with an extreme rate of > 700 cM/Mb in a 67-kb segment. We find no signatures of sexual antagonism and propose that sexual antagonism may have limited influence on PAR sequences when sex chromosomes are nearly fully differentiated and when a recombination hotspot region is located close to the PAR boundary. Our results demonstrate that a very small PAR suffices to ensure homologous recombination and proper segregation of sex chromosomes during meiosis.

Place, publisher, year, edition, pages
2014. Vol. 5, 5448- p.
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Evolutionary Biology
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URN: urn:nbn:se:uu:diva-240243DOI: 10.1038/ncomms6448ISI: 000345909200001PubMedID: 25378102OAI: oai:DiVA.org:uu-240243DiVA: diva2:776239
Available from: 2015-01-07 Created: 2015-01-06 Last updated: 2017-12-05Bibliographically approved

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Smeds, LinneaKawakami, TakeshiBurri, RetoBolivar, PaulinaQvarnström, AnnaUebbing, SeverinEllegren, Hans

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