Developmental exposure to the polybrominated diphenylether PBDE 209: Neurobehavioural and neuroprotein analysis in adult male and female mice
2014 (English)In: Environmental Toxicology and Pharmacology, ISSN 1382-6689, Vol. 38, 570-585 p.Article in journal (Refereed) Published
Polybrominated diphenyl ethers (PBDEs), used as flame retardants in polymer products,are reported to cause developmental neurotoxic effects in mammals. The present studyhave investigated neurotoxic effects arising from neonatal exposure to PBDE 209, includingalterations in sex differences, spontaneous behaviour, learning and memory, neuroproteinsand altered susceptibility of the cholinergic system in adults.Three-day-old NMRI mice, of both sexes, were exposed to PBDE 209 (2,2,3,3,4,4,5,5,6,6-decaBDE at 0, 1.4, 6.0 and 14.0 mol/kg b.w.). At adult age (2–7 months) a similardevelopmental neurotoxic effects in both male and female mice were seen, including lackof or reduced habituation to a novel home environment, learning and memory defects,modified response to the cholinergic agent’s paraoxon (males) and nicotine (females) indi-cating increased susceptibility of the cholinergic system. The behavioural defects weredose–response related and persistent. In mice of both sexes and showing behaviouraldefects, neuroprotein tau was increased.
Place, publisher, year, edition, pages
2014. Vol. 38, 570-585 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:uu:diva-240574DOI: 10.1016/j.etap.2014.08.010PubMedID: 25194327OAI: oai:DiVA.org:uu-240574DiVA: diva2:776722