uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Developmental exposure to the polybrominated diphenylether PBDE 209: Neurobehavioural and neuroprotein analysis in adult male and female mice
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
2014 (English)In: Environmental Toxicology and Pharmacology, ISSN 1382-6689, E-ISSN 1872-7077, Vol. 38, 570-585 p.Article in journal (Refereed) Published
Abstract [en]

Polybrominated diphenyl ethers (PBDEs), used as flame retardants in polymer products,are reported to cause developmental neurotoxic effects in mammals. The present studyhave investigated neurotoxic effects arising from neonatal exposure to PBDE 209, includingalterations in sex differences, spontaneous behaviour, learning and memory, neuroproteinsand altered susceptibility of the cholinergic system in adults.Three-day-old NMRI mice, of both sexes, were exposed to PBDE 209 (2,2,3,3,4,4,5,5,6,6-decaBDE at 0, 1.4, 6.0 and 14.0 mol/kg b.w.). At adult age (2–7 months) a similardevelopmental neurotoxic effects in both male and female mice were seen, including lackof or reduced habituation to a novel home environment, learning and memory defects,modified response to the cholinergic agent’s paraoxon (males) and nicotine (females) indi-cating increased susceptibility of the cholinergic system. The behavioural defects weredose–response related and persistent. In mice of both sexes and showing behaviouraldefects, neuroprotein tau was increased.

Place, publisher, year, edition, pages
2014. Vol. 38, 570-585 p.
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-240574DOI: 10.1016/j.etap.2014.08.010PubMedID: 25194327OAI: oai:DiVA.org:uu-240574DiVA: diva2:776722
Available from: 2015-01-08 Created: 2015-01-08 Last updated: 2017-12-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Buratovic, SonjaViberg, HenrikFredriksson, AndersEriksson, Per

Search in DiVA

By author/editor
Buratovic, SonjaViberg, HenrikFredriksson, AndersEriksson, Per
By organisation
Environmental toxicology
In the same journal
Environmental Toxicology and Pharmacology
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 511 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf