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Hallmarks of gastrointestinal neuroendocrine tumours: implications for treatment
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2014 (English)In: Endocrine-Related Cancer, ISSN 1351-0088, E-ISSN 1479-6821, Vol. 21, no 6, R445-R460 p.Article, review/survey (Refereed) Published
Abstract [en]

In the past few years, there have been advances in the treatment of neuroendocrine tumours (NETs) and improvements in our understanding of NET biology. However, the benefits to patients have been relatively modest and much remains yet to be done. The 'Hallmarks of Cancer', as defined by Hanahan and Weinberg, provide a conceptual framework for understanding the aberrations that underlie tumourigenesis and to help identify potential targets for therapy. In this study, our objective is to review the major molecular characteristics of NETs, based on the recently modified 'Hallmarks of Cancer', and highlight areas that require further research.

Place, publisher, year, edition, pages
2014. Vol. 21, no 6, R445-R460 p.
Keyword [en]
cancer, neuroendocrine tumours, treatment, tumourigenesis
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Cancer and Oncology Endocrinology and Diabetes
URN: urn:nbn:se:uu:diva-240849DOI: 10.1530/ERC-14-0106ISI: 000344788600003PubMedID: 25296914OAI: oai:DiVA.org:uu-240849DiVA: diva2:777160
Available from: 2015-01-08 Created: 2015-01-08 Last updated: 2015-01-08Bibliographically approved

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Öberg, Kjell
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