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Biomimetic Hydroxyapatite Coated Titanium Screws Demonstrate Rapid Implant Stabilization and Safe Removal In-Vivo
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanoteknologi och funktionella material)
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2015 (English)In: Journal of Biomaterials and Nanobiotechnology, ISSN 2158-7027, E-ISSN 2158-7043, Vol. 6, 20-35 p.Article in journal (Refereed) Published
Abstract [en]

The early fixation of bone screws after surgical implantation still remains a challenge in the field

of traumatology. Whilst hydroxyapatite (HA) coatings are known to enhance the fixation of implants;

their removal at a later time-point may be problematic. An HA coating has been developed

to demonstrate that both implant fixation and safe removal are feasible in the same design. Accordingly

the aim of this study was to compare the in-vivo performance of thin biomimetic HA coated

titanium screws to uncoated counterparts used as control after bilateral implantation in the femoral

condyle of 36 New Zealand White Rabbits. The screws were analysed macroscopically, by

histology, micro-CT and biomechanically at both two and six weeks post-implantation. The HA

coated screws demonstrated excellent biocompatibility. At two weeks the HA coated screws demonstrated

a significant increase in removal torque values as well as a strong trend towards higher

pull-out forces. In addition histology confirmed a higher degree of osseointegration and direct

bone to implant contact. At six weeks no difference in pull-out force and removal torque could be

detected. SEM images confirmed the absence of any residual HA coating indicating a fast coating

degradation in-vivo. The low level of removal torque after full osseointegration at 6 weeks supports

the feasibility of safe and easy removal of the implant. The HA coating under study appears

to offer a unique characteristic of enhanced fixation with a minimal increase in removal torque

after full osseointegration. This may be of value in clinical applications where it is necessary to

assure both screw fixation and later removal.

Place, publisher, year, edition, pages
2015. Vol. 6, 20-35 p.
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials; Engineering Science with specialization in Materials Science
URN: urn:nbn:se:uu:diva-241736DOI: 10.4236/jbnb.2015.61003OAI: oai:DiVA.org:uu-241736DiVA: diva2:781357
Available from: 2015-01-16 Created: 2015-01-16 Last updated: 2015-06-30

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Welch, KenEngqvist, HåkanStrömme, Maria
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