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Biased Estimates of Diminishing-Returns Epistasis?: Empirical Evidence Revisited
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
2014 (English)In: Genetics, ISSN 0016-6731, E-ISSN 1943-2631, Vol. 198, no 4, 1417-1420 p.Article in journal (Refereed) Published
Abstract [en]

Empirical evidence for diminishing fitness returns of beneficial mutations supports Fisher's geometric model. We show that a similar pattern emerges through the phenomenon of regression to the mean and that few studies correct for it. Although biases are often small, regression to the mean has overemphasized diminishing returns and will hamper cross-study comparisons unless corrected for.

Place, publisher, year, edition, pages
2014. Vol. 198, no 4, 1417-1420 p.
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Genetics
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URN: urn:nbn:se:uu:diva-241422DOI: 10.1534/genetics.114.169870ISI: 000346059300007PubMedID: 25313131OAI: oai:DiVA.org:uu-241422DiVA: diva2:781906
Available from: 2015-01-19 Created: 2015-01-12 Last updated: 2017-12-05Bibliographically approved

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Berger, David

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