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Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, Malmö, Sweden.
Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, Malmö, Sweden.
Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, Malmö, Sweden.
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1999 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 256, no 3, 557-563 p.Article in journal (Refereed) Published
Abstract [en]

The mammalian achaete-scute homologue, MASH-1, is crucial for early development of the sympathetic nervous system and is transiently expressed in sympathetic neuroblasts during embryogenesis. Here we report that the human homologue (HASH-1) was expressed in all analyzed cell lines (6/6) derived from the sympathetic nervous system tumor neuroblastoma. The majority of small-cell lung carcinoma (4/5) cell lines tested expressed HASH-1, while other nonneuronal/non-neuroendocrine cell lines were negative. Induced differentiation of neuroblastoma cells resulted in HASH-1 downregulation. This occurred concomitant with induction of neurite outgrowth and expression of the neuronal marker genes GAP-43 and neuropeptide Y. Constitutive expression of exogenous HASH-1 did not alter the capacity of the neuroblastoma cells to differentiate in response to differentiation-inducing agents. It is concluded that moderate HASH-1 expression does not compromise the capacity of these cells to differentiate.

Place, publisher, year, edition, pages
1999. Vol. 256, no 3, 557-563 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-241982DOI: 10.1006/bbrc.1999.0314PubMedID: 10080936OAI: oai:DiVA.org:uu-241982DiVA: diva2:781960
Available from: 2015-01-19 Created: 2015-01-19 Last updated: 2017-12-05Bibliographically approved

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Söderholm, Helena

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