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Combined lowering of low grade systemic inflammation and insulin resistance in metabolic syndrome patients treated with Ginkgo biloba
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2014 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 237, no 2, 584-588 p.Article in journal (Refereed) Published
Abstract [en]

In a clinical pilot study with eleven metabolic syndrome patients, a simultaneous decrease in hs-CRP from 8.85 +/- 4.09 to 4.92 +/- 2.51 mg/L (-44.4%) (p < 0.0436) and HOMA-IR from 3.07 +/- 0.63 to 2.60 +/- 0.51 mU/L x mg/dL (-15.3%) (p < 0.0120) as well as a beneficial change of arteriosclerotic, inflammatory and oxidative stress biomarkers were detected after 2-month treatment with Ginkgo biloba. Furthermore, both IL-6 (-12.9%, p < 0.0407) and nanoplaque formation (-14.3%, p < 0.0077) were additionally reduced. According to a large clinical trial elucidating the importance of insulin resistance and low-grade systemic inflammation for cardiovascular disease and overall mortality risk, these data might indicate a CVD/total mortality risk reduction.

Place, publisher, year, edition, pages
2014. Vol. 237, no 2, 584-588 p.
Keyword [en]
Metabolic syndrome patients, High-sensitivity C-reactive protein (hs-CRP), Homeostasis model assessment of insulin resistance (HOMA-IR), CVD/total mortality risk, Ginkgo biloba
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-241413DOI: 10.1016/j.atherosclerosis.2014.10.023ISI: 000346066600061PubMedID: 25463092OAI: oai:DiVA.org:uu-241413DiVA: diva2:781983
Available from: 2015-01-19 Created: 2015-01-12 Last updated: 2017-12-05Bibliographically approved

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Siegel, Günter

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