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Sustained prognostic implications of newly detected glucose abnormalities in patients with acute myocardial infarction: Longterm follow-up of the Glucose Tolerance in Patients with Acute Myocardial Infarction cohort
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
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2015 (English)In: Diabetes & Vascular Disease Research, ISSN 1479-1641, E-ISSN 1752-8984, Vol. 12, no 1, 23-32 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate long-term prognostic importance of newly discovered glucose disturbances in patients with acute myocardial infarction (AMI). Methods: During 1998-2001, consecutive patients with AMI (n=167) and healthy controls (n=184) with no previously known diabetes were investigated with an oral glucose tolerance test (OGTT). Patients and controls were separately followed up for cardiovascular events (first of cardiovascular mortality/AMI/stroke/heart failure) during a decade. Results: In all, 68% of the patients and 35% of the controls had newly detected abnormal glucose tolerance (AGT). Cardiovascular event (n=72, p=0.0019) and cardiovascular mortality (n=31, p=0.031) were more frequent in patients with newly detected AGT. Regarding patients, a Cox proportional-hazard regression analysis identified AGT (hazard ratio (HR): 2.30; 95% confidence interval (CI): 1.24-4.25; p=0.008) and previous AMI (HR: 2.39; CI: 1.31-4.35; p=0.004) as prognostically important. Conclusion: An OGTT at discharge after AMI disclosed a high proportion of patients with previously unknown AGT which had a significant and independent association with long-term prognosis.

Place, publisher, year, edition, pages
2015. Vol. 12, no 1, 23-32 p.
Keyword [en]
Myocardial infarction, prognosis, diabetes, impaired glucose tolerance, oral glucose tolerance test
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:uu:diva-241938DOI: 10.1177/1479164114551746ISI: 000346345200003OAI: oai:DiVA.org:uu-241938DiVA: diva2:782270
Available from: 2015-01-20 Created: 2015-01-19 Last updated: 2015-01-20Bibliographically approved

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