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Neurosteroids and Alzheimer’s disease: Mechanistic studies of neuroprotection and neurogenesis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2015 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Alzheimer’s disease (AD) and its consequent memory and cognitive impairments continue to be unhaltable and incurable to this day. Yet, recent studies demonstrating neuroprotective effects of some neurosteroids have shown a potential of these steroids to modulate AD progression in vitro and in vivo. In the present study, the effects of neurosteroids were studied on hydrogen peroxide (H2O2), as well as staurosporine-induced toxicity in SH-SY5Y neuroblastoma cells. Moreover, underlying mechanisms were investigated. Cell viability was measured with MTT-assay. The results demonstrated that the neurosteroids investigated reduced hydrogen peroxide-induced toxicity. One of the neurosteroid even reduced staurosporine-induced toxicity. Moreover, the present study also showed neurogenic properties for one of the neurosteroid studied.  In conclusion, this report demonstrates that neurosteroids act neuroprotective against hydrogen peroxide-induced toxicity and that one of the neurosteroids studied even acts neuroprotective against staurosporine-induced toxicity and possesses neurogenic effects. 

Place, publisher, year, edition, pages
2015. , 38 p.
Keyword [en]
Alzheimer's disease, neuroprotection, neurogenesis, oxidative stress, apoptosis, neurosteroids
Keyword [sv]
alzheimers sjukdom, neurosteroider, apoptos, neurogenes, oxidativ stress, neuroprotektion
National Category
Pharmacology and Toxicology
URN: urn:nbn:se:uu:diva-242572OAI: oai:DiVA.org:uu-242572DiVA: diva2:784068
Subject / course
Pharmaceutical Pharmacology
Educational program
Master of Science Programme in Pharmacy
Available from: 2015-02-02 Created: 2015-01-28 Last updated: 2015-02-02Bibliographically approved

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