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Halogenated Dodecaborate Clusters as Agents to Trigger Release of Liposomal Contents
Department of Biochemistry, Alexandria University, Egypt AND Department of Chemistry, University of Bremen, Germany AND Jacobs University Bremen, Germany.
Department of Chemistry, University of Bremen, Germany AND Jacobs University Bremen, Germany.
Department of Chemistry, University of Bremen, Germany.
Department of Chemistry, University of Bremen, Germany.
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2015 (English)In: ChemPlusChem, ISSN 2192-6506, Vol. 80, no 4, p. 656-664Article in journal (Refereed) Published
Abstract [en]

Halogenated dodecaborates, and especially dodecaiodododecaborate(2−), are found to trigger effectively the release of the contents of phospholipid liposomes, including liposomes containing distearoylphosphatidylcholine and cholesterol, which are used clinically in cancer therapy. The basis of the release is studied through differential scanning calorimetry, cryo-transmission electron microscopy, and atomic force microscopy. Upon administration at high concentrations, drastic morphological changes are induced by the dodecaborates. Their possible use in triggered release is suggested.

Place, publisher, year, edition, pages
2015. Vol. 80, no 4, p. 656-664
Keywords [en]
boron, cluster compounds, cryo-transmission electron microscopy, differential scanning calorimetry, liposomes, triggered release
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-242705DOI: 10.1002/cplu.201402286ISI: 000352707900003OAI: oai:DiVA.org:uu-242705DiVA, id: diva2:784702
Available from: 2015-01-30 Created: 2015-01-30 Last updated: 2015-05-11Bibliographically approved

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Publisher's full texthttp://dx.doi.org/10.1002/cplu.201402286

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Eriksson, JonnyEdwards, Katarina

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