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Podophyllotoxin derivatives: drug discovery and development
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
1996 (English)In: Drug Discovery Today, ISSN 1359-6446, E-ISSN 1878-5832, Vol. 1, no 8, 343-351 p.Article, review/survey (Refereed) Published
Abstract [en]

The exploration and exploitation of podophyllin formulations provide an example of how a plant extract with established ethnomedical use, but also causing toxicity, can provide a basis for new drug discovery and development. Applications and potential applications include the treatment of venereal warts, psoriasis, rheumatoid arthritis, malaria and Alzheimer's disease. This review addresses the history and pharmacological action of these natural products and outlines the preclinical development and clinical trials of drugs in the pipeline and with marketing approval.

Place, publisher, year, edition, pages
Elsevier , 1996. Vol. 1, no 8, 343-351 p.
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-50621DOI: 10.1016/1359-6446(96)10028-3OAI: oai:DiVA.org:uu-50621DiVA: diva2:78529
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-07-21Bibliographically approved

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