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Amentoflavone from Biophytum sensitivum and its effect on COX-1/COX-2 catalysed prostaglandin biosynthesis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
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1998 (English)In: Planta Medica, ISSN 0032-0943, Vol. 64, no 4, 373-374 p.Article in journal (Refereed) Published
Abstract [en]

Amentoflavone (13′, ll8-biapigenin) was isolated from the roots of Biophytum sensitivum DC. (Oxalidaceae) and proved to be a selective inhibitor of cyclooxygenase (COX)-1 catalysed prostaglandin biosynthesis when tested in vitro with an IC50 value of 12.4 µM (standard: indomethacin, IC50 = 1.1 µM). Doses of up to 37 µM showed only a slight inhibition in the corresponding COX-2 assay. Quantification of amentoflavone was carried out by reversed phase HPLC in methanolic and aqueous extracts of the roots, stems and leaves. Highest amounts of amentoflavone were detected in methanolic extracts of roots and stems (0.26-0.35%), while considerably lower amounts were detected in the corresponding water extracts.

Place, publisher, year, edition, pages
Thieme , 1998. Vol. 64, no 4, 373-374 p.
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-50641DOI: 10.1055/s-2006-957455OAI: oai:DiVA.org:uu-50641DiVA: diva2:78549
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-07-21Bibliographically approved

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