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The flavonoid constituents of two Polypodium species (Calaguala) and their effect on the elastase release in human neutrophils
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
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1997 (English)In: Planta Medica, ISSN 0032-0943, E-ISSN 1439-0221, Vol. 63, no 6, 511-517 p.Article in journal (Refereed) Published
Abstract [en]

Five flavonoid compounds were isolated from two Polypodium species (P.decumanum and P.triseriale) with the common name Calaguala. Structure elucidation was carried out using different NMR techniques and revealed the presence of one new glycoside (kaempferol 3-O-beta-D-xylopyranosyl-(1-2)-beta-D-arabinopyranoside) (1), two known flavonoid glycosides, rutin and kaempferol 3-O-alpha-D-arabinopyranoside (2,3), the trimeric proanthocyanidin, selligueain (4), and the coumarinic acid derivative, melilotoside (5). The compounds were tested for their activity in PAF induced exocytosis in human neutrophils but none of the compounds showed PAF specific activity. Instead, they showed more general effects on the neutrophil including inhibition of the spontaneous elastase release (5) and potentiation of the release induced by PAF (1). Selligueain was found to inhibit the proteolytic enzyme, elastase in vitro.

Place, publisher, year, edition, pages
1997. Vol. 63, no 6, 511-517 p.
Keyword [en]
Calaguala, Polypodium decumanum, Polypodium triseriale, Polypodiaceae, platelet activating factor, flavonoids, human neutrophil, elastase release
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-50648DOI: 10.1055/s-2006-957753ISI: 000071317600006PubMedID: 9434602OAI: oai:DiVA.org:uu-50648DiVA: diva2:78556
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-05Bibliographically approved

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