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New acetylenes isolated from the bark of Heisteria acuminata
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1998 (English)In: Journal of natural products (Print), ISSN 0163-3864, E-ISSN 1520-6025, Vol. 61, no 4, 422-427 p.Article in journal (Refereed) Published
Abstract [en]

Five new linear acetylenic compounds, namely, pentadeca-6,8,10-triynoic acid (1), octadeca-8,10,12-triynoic acid (2), trans-pentadec-10-en-6,8-diynoic acid (3), cis-hexadec-11-en-7,9-diynoic acid (4), and cis-octadec-12-en-7,9-diynoic acid (5), were isolated from the bark of Heisteria acuminata by bioassay-guided fractionation, using cyclooxygenase (COX) and 5-lipoxygenase (5-LO) assays as models for antiinflammatory activity. The structures of compounds 1-5 were established by NMR, MS, IR, and Raman spectroscopy. These isolated compounds were found to be potent inhibitors of COX. Compounds 4 and 5 were the most potent inhibitors of 5-LO, whereas the other compounds only showed a weak inhibition at the same concentration.

Place, publisher, year, edition, pages
1998. Vol. 61, no 4, 422-427 p.
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Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-50651DOI: 10.1021/np970357pISI: 000073339100002PubMedID: 9584394OAI: oai:DiVA.org:uu-50651DiVA: diva2:78559
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-10-26Bibliographically approved

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