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Hippocampal dynorphin B injections impair spatial learning in rats: a kappa-opioid receptor-mediated effect
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Pharmacology)
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1998 (English)In: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Vol. 85, no 2, 375-382 p.Article in journal (Refereed) Published
Abstract [en]

The hippocampus plays a central role in the acquisition and storage of information. Long-term potentiation in the mossy fibre pathway to the CA3 region in the hippocampus, an animal model of memory acquisition, is modulated by dynorphin peptides. This study investigated the possible role of hippocampal dynorphin in spatial learning. Male rats were trained in the Morris Water Task after microinjection with different doses of dynorphin B (1, 3.3 or 10 nmol/rat) or artificial cerebrospinal fluid (as control) into the CA3 region of the dorsal hippocampus. Dynorphin B was found to impair spatial learning at all tested doses. The synthetic kappa1-selective opiate receptor antagonist nor-binaltorphimine (2 nmol) also given into the hippocampus fully blocked the acquisition impairment caused by dynorphin B (10 nmol), while nor-binaltorphimine alone did not affect learning performance. These findings suggest that dynorphin peptides could play a modulatory role in hippocampal plasticity by acting on hippocampal kappa-receptors and thereby impair spatial learning.

Place, publisher, year, edition, pages
1998. Vol. 85, no 2, 375-382 p.
Keyword [en]
dynorphin, nor-binaltorphimine, hippocampus, spatial learning, kappa-receptors
National Category
Medical and Health Sciences Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-50732DOI: 10.1016/S0306-4522(97)00605-2ISI: 000073664400006PubMedID: 9622237OAI: oai:DiVA.org:uu-50732DiVA: diva2:78641
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-03-10Bibliographically approved

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Nylander, Ingrid
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