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Metabolism-dependent activation and toxicity of chemicals in nasal glands
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Toxicology)
1997 (English)In: Mutation research, ISSN 0027-5107, E-ISSN 1873-135X, Vol. 380, no 1-2, 61-75 p.Article in journal (Refereed) Published
Abstract [en]

The mucosae of the nasal passages contain a large amount of glands which express secretory proteins as well as phase I and phase II biotransformation enzymes. In this review the metabolic activation, covalent binding and toxicity of chemicals in the Bowman's glands in the olfactory mucosa, in the sere-mucous glands in the nasal septum and in the lateral nasal glands and maxillary glands around the maxillary sinuses are discussed. Light microscopic autoradiographic studies have demonstrated a selective covalent binding of nasal toxicants and carcinogens such as halogenated hydrocarbons and N-nitrosamines, especially in the Bowman's glands following a single systemic exposure, suggesting a high rate of metabolic activation of chemicals in these glands. Special attention is put on the herbicide dichlobenil which induces necrosis in the olfactory mucosa following a cytochrome-P450-mediated metabolic activation and covalent binding in the Bowman's glands.

Place, publisher, year, edition, pages
1997. Vol. 380, no 1-2, 61-75 p.
Keyword [en]
Bowman's gland, sero-mucous gland, lateral nasal gland, maxillary gland, olfactory mucosa, nasal mucosa, nasal toxicity, nasal P450, dichlobenil
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-50764DOI: 10.1016/S0027-5107(97)00127-9ISI: A1997YE98400008PubMedID: 9385390OAI: oai:DiVA.org:uu-50764DiVA: diva2:78673
Available from: 2005-05-26 Created: 2005-05-26 Last updated: 2017-12-04Bibliographically approved

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Brittebo, Eva B

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