Genetic studies of body mass index yield new insights for obesity biology
2015 (English)In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 518, no 7538, 197-206 p.Article in journal (Refereed) Published
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
Place, publisher, year, edition, pages
2015. Vol. 518, no 7538, 197-206 p.
IdentifiersURN: urn:nbn:se:uu:diva-244272DOI: 10.1038/nature14177ISI: 000349190300031PubMedID: 25673413OAI: oai:DiVA.org:uu-244272DiVA: diva2:788346
De fem sista författarna delar sistaförfattarskapet.2015-02-132015-02-132016-09-23Bibliographically approved