uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Genetic studies of body mass index yield new insights for obesity biology
Show others and affiliations
2015 (English)In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 518, no 7538, p. 197-206Article in journal (Refereed) Published
Abstract [en]

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Place, publisher, year, edition, pages
2015. Vol. 518, no 7538, p. 197-206
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:uu:diva-244272DOI: 10.1038/nature14177ISI: 000349190300031PubMedID: 25673413OAI: oai:DiVA.org:uu-244272DiVA, id: diva2:788346
Note

De fem sista författarna delar sistaförfattarskapet.

Available from: 2015-02-13 Created: 2015-02-13 Last updated: 2018-07-06Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Fall, ToveGustafsson, StefanHedman, Åsa KÄrnlöv, JohanBerne, ChristianGiedraitis, VilmantasJohansson, ÅsaLind, LarsSundström, JohanSyvänen, Ann-ChristineGyllensten, UlfIngelsson, Erik

Search in DiVA

By author/editor
Fall, ToveGustafsson, StefanHedman, Åsa KÄrnlöv, JohanBerne, ChristianGiedraitis, VilmantasJohansson, ÅsaLind, LarsSundström, JohanSyvänen, Ann-ChristineGyllensten, UlfIngelsson, Erik
By organisation
Molecular epidemiologyScience for Life Laboratory, SciLifeLabClinical diabetology and metabolismGeriatricsMedicinsk genetik och genomikCardiovascular epidemiologyMolecular Medicine
In the same journal
Nature
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 1120 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf