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Distribution of tripeptidyl-peptidase II in the central nervous system of rat
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Drug Dependence)
1995 (English)In: Neurochemical Research, ISSN 0364-3190, E-ISSN 1573-6903, Vol. 20, no 12, 1443-1447 p.Article in journal (Refereed) Published
Abstract [en]

Tripeptidyl-peptidase II (TPP II) is a high molecular weight serine peptidase which removes tripeptides from a free N-terminus of longer peptides. Since it had previously been demonstrated that the enzyme can inactivate enkephalins and dynorphins in vitro by removing the N-terminal Tyr-Gly-Gly peptide, we wanted to see whether TPP II could be involved in this process also in vivo. Therefore, the localization of TPP II in different cerebral regions of rat was investigated by immunoblot analysis and activity measurements. It could be shown that TPP II is relatively evenly distributed in the central nervous system of rat. This indicates that the physiological role of the enzyme is probably not a specific degradation of enkephalins, but rather pertains to the general turnover of proteins.

Place, publisher, year, edition, pages
1995. Vol. 20, no 12, 1443-1447 p.
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Pharmaceutical Sciences Natural Sciences
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URN: urn:nbn:se:uu:diva-50929DOI: 10.1007/BF00970592PubMedID: 8789606OAI: oai:DiVA.org:uu-50929DiVA: diva2:78838
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-04Bibliographically approved

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Tomkinson, Birgitta

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