uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Sialic acid and incidence of hospitalization for diabetes and its complications during 40-years of follow-up in a large cohort: The Varmland survey
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.ORCID iD: 0000-0003-2247-8454
Show others and affiliations
2014 (English)In: Primary Care Diabetes, ISSN 1751-9918, E-ISSN 1878-0210, Vol. 8, no 4, 352-357 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To examine the association of sialic acid (SA) with first recorded diabetes mellitus-related hospitalization. Methods: From a population-based study in Varmland, Sweden, between 1962 and 1965, 87,035 men and women were selected and followed for first recorded diabetes-related hospitalization until 2005. The association of SA was calculated and stratified for gender by Cox's proportional hazards models. Adjustments were made for conventional risk factors and socioeconomic status. Association analyses were made for comparisons between SA-levels above and below median. Results: The mean age was 47.2 (SD 13.0) years and the total numbers of incident diabetes-related hospitalizations in men and women were 3445 and 3273, respectively. Hazard ratios per one standard deviation of SA were 1.12 (95% CI: 1.08-1.17, p < 0.0001) in men and 1.17 (95% CI: 1.13-1.22, p < 0.0001) in women. Interaction analyses indicated a relatively higher SA-associated risk in women than in men with above median SA levels. Conclusions: In this large population-based cohort followed for more than 40 years, elevated SA, as a marker of systemic inflammation, was independently associated with risk of diabetes and diabetes-related hospitalizations.

Place, publisher, year, edition, pages
2014. Vol. 8, no 4, 352-357 p.
Keyword [en]
Epidemiology, Diabetes mellitus, Inflammation, Population, Sialic acid
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:uu:diva-243698DOI: 10.1016/j.pcd.2014.06.002ISI: 000347508500011PubMedID: 24996911OAI: oai:DiVA.org:uu-243698DiVA: diva2:788763
Available from: 2015-02-16 Created: 2015-02-11 Last updated: 2016-01-18Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Sundström, Johan
By organisation
In the same journal
Primary Care Diabetes
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 144 hits
ReferencesLink to record
Permanent link

Direct link