Microdialysis in CNS PKPD research: Unraveling unbound concentrations
2013 (English)In: Microdialysis in drug development / [ed] Müller M, New York Heidelberg Dordrecht London: Springer , 2013, 83-102 p.Chapter in book (Refereed)
With the help of microdialysis sampling, we can describe pharmacokinetic processes of drug movement between blood and tissues, and can describe concentration profiles within a tissue over time. Not only this, but the fact that microdialysis measures the unbound, pharmacologically active drug concentration are unique features of the technique, not possible to obtain directly with any other method. These are the most valuable outcomes of the technique for PKPD studies, and are the basis for the description of the principles of CNS drug distribution and PKPD presented in this chapter. This chapter will cover microdialysis studies performed to investigate PK and PKPD relationships of the CNS, and also alternative methods to microdialysis when this technique does not work or when it is too slow in i.e. drug discovery.
Place, publisher, year, edition, pages
New York Heidelberg Dordrecht London: Springer , 2013. 83-102 p.
, AAPS advances in the pharmaceutical sciences, ISSN 2210-7371 ; 4
Research subject Pharmaceutical Science
IdentifiersURN: urn:nbn:se:uu:diva-244793DOI: 10.1007/978-1-4614-4815-0ISBN: 978-1-4614-4814-3OAI: oai:DiVA.org:uu-244793DiVA: diva2:789857