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In vivo approaches to assessing the blood-brain barrier
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (PKPD)
2014 (English)In: The blood-brain barrier (BBB) / [ed] Fricker G, Ott M, Mahringer A, Heidelberg New York Dordrecht London: Springer , 2014, 21-48 p.Chapter in book (Refereed)
Abstract [en]

Methods for in vivo assessment of blood-brain barrier (BBB) transport are presented, with their advantages and disadvantages. The methods described are brain uptake index, the i.v. injection technique, in situ brain perfusion, brain efflux index, % injected dose, microdialysis, CSF sampling and positron emission tomography, and the combinatorial mapping of unbound drug partitioning across the BBB. The methods are put into a pharmacokinetic context by delineating the type of readings that they give, be it the rate of transport across the BBB or the extent of transport of total drug (unbound and bound), or of the unbound drug.

Place, publisher, year, edition, pages
Heidelberg New York Dordrecht London: Springer , 2014. 21-48 p.
Series
Topics in medicinal chemistry, ISSN 1862-2461 ; 10
National Category
Pharmaceutical Sciences Neurosciences
Research subject
Pharmaceutical Science
Identifiers
URN: urn:nbn:se:uu:diva-244795DOI: 10.1007/978-3-662-43787-2ISBN: 978-3-662-43786-5 (print)OAI: oai:DiVA.org:uu-244795DiVA: diva2:789861
Available from: 2015-02-20 Created: 2015-02-20 Last updated: 2015-02-20

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Hammarlund-Udenaes, Margareta

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