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Stochastic anomaly detection in eye-tracking data for quantification of motor symptoms in Parkinson's disease
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
2015 (English)In: Signal and Image Analysis for Biomedical and Life Sciences, Springer, 2015, 63-82 p.Chapter in book (Refereed)
Abstract [en]

Two methods for distinguishing between healthy controls and patients diagnosed with Parkinson's disease by means of recorded smooth pursuit eye movements are presented and evaluated. Both methods are based on the principles of stochastic anomaly detection and make use of orthogonal series approximation for probability distribution estimation. The first method relies on the identification of a Wiener model of the smooth pursuit system and attempts to find statistically significant differences between the estimated parameters in healthy controls and patients with Parkinson's disease. The second method applies the same statistical method to distinguish between the gaze trajectories of healthy and Parkinson subjects tracking visual stimuli. Both methods show promising results, where healthy controls and patients with Parkinson's disease are effectively separated in terms of the considered metric. The results are preliminary because of the small number of participating test subjects, but they are indicative of the potential of the presented methods as diagnosing or staging tools for Parkinson's disease.

Place, publisher, year, edition, pages
Springer, 2015. 63-82 p.
Series
Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 823
National Category
Control Engineering Neurology
Identifiers
URN: urn:nbn:se:uu:diva-244824DOI: 10.1007/978-3-319-10984-8_4ISI: 000350427300005PubMedID: 25381102ISBN: 978-3-319-10983-1 (print)OAI: oai:DiVA.org:uu-244824DiVA: diva2:789918
Available from: 2014-10-13 Created: 2015-02-20 Last updated: 2015-04-16Bibliographically approved

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Jansson, DanielMedvedev, AlexanderAxelson, HansNyholm, Dag

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