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Selenium status in pregnancy influences children's cognitive function at 1.5 years of age
Unit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
International Center for Diarrheal Disease Research, Dhaka, Bangladesh.
International Center for Diarrheal Disease Research, Dhaka, Bangladesh.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH). (Internationell barnhälsa och nutrition/Persson)
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2015 (English)In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 34, no 5, 923-930 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND & AIMS: Selenium deficiency has been shown to affect the neurological development in animals, but human research in this area is scarce. We aimed to assess the impact of selenium status during pregnancy on child development at 1.5 years of age.

METHODS: This prospective cohort study was nested into a food and micronutrient supplementation trial (MINIMat) conducted in rural Bangladesh. Using inductively coupled plasma mass spectrometry, we measured selenium concentrations in erythrocyte fraction of blood collected from 750 mothers at gestational week 30, and calculated μg per g hemoglobin. A revised version of Bayley Scales of Infant Development was used to assess children's mental and psychomotor development. A Bangladeshi version of MacArthur's Communicative Development Inventory was used to assess language comprehension and expression. Linear regression analyses adjusted for multiple covariates were used to assess the associations.

RESULTS: Maternal erythrocyte selenium concentrations varied considerably, from 0.19 to 0.87 μg/g hemoglobin (median 0.46 μg/g hemoglobin), and were associated with developmental measures. An increase in erythrocyte selenium by 0.50 μg/g hemoglobin was associated with an increase in children's language comprehension by 3.7 points (0.5 standard deviations; 95% confidence interval: 0.40, 7.1; p = 0.028). The same increase in erythrocyte selenium corresponded to an increase in the girls' psychomotor development by 12 points (0.9 standard deviation; 95% confidence interval: 4.3, 19; p = 0.002), but much less in boys.

CONCLUSIONS: Low prenatal selenium status seems to be disadvantageous for children's psychomotor and language development. Further studies are needed to elucidate the underlying mechanisms of these effects.

Place, publisher, year, edition, pages
2015. Vol. 34, no 5, 923-930 p.
National Category
Nutrition and Dietetics
URN: urn:nbn:se:uu:diva-245093DOI: 10.1016/j.clnu.2014.09.020ISI: 000360949800020PubMedID: 25444556OAI: oai:DiVA.org:uu-245093DiVA: diva2:790478
Sida - Swedish International Development Cooperation AgencySwedish Research Council, 2013-24825-103693-45Swedish Research Council Formas
Available from: 2015-02-24 Created: 2015-02-24 Last updated: 2015-10-06Bibliographically approved

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