A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones
2015 (English)In: Organic and biomolecular chemistry, ISSN 1477-0520, E-ISSN 1477-0539, Vol. 13, no 7, 2044-2054 p.Article in journal (Refereed) Published
A microwave-assisted, multicomponent protocol for the synthesis of substituted 3,4-dihydroquinazolinones via a novel cascade imine/cyclization/aza-Henry reaction sequence is reported. Starting from o-formyl carbamates, a series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a cyclic iminium ion intermediate in moderate to excellent yields. Notably, the reaction is fast, flexible, simple to perform and tolerates a variety of functional groups.
Place, publisher, year, edition, pages
2015. Vol. 13, no 7, 2044-2054 p.
IdentifiersURN: urn:nbn:se:uu:diva-245140DOI: 10.1039/c4ob02417fISI: 000349401300016PubMedID: 25518892OAI: oai:DiVA.org:uu-245140DiVA: diva2:790590