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Synthesis of enantiomerically pure cis and trans 2-aminocyclopentanecarboxylic acids. Use of proline replacements in potential HIV-protease inhibitors
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1997 (English)In: Tetrahedron, ISSN 0040-4020, E-ISSN 1464-5416, Vol. 53, no 23, 7975-7984 p.Article in journal (Refereed) Published
Abstract [en]

The synthesis of the four diastereomeric 2-aminocyclopentanecarboxylic acids, their use as replacements for proline in potential HIV protease inhibitors containing a hydroxyethylamine dipeptide isostere and the evaluation of the biological activity of these is described.

Place, publisher, year, edition, pages
1997. Vol. 53, no 23, 7975-7984 p.
Keyword [en]
ORGANIC-REACTIONS; ALUMINA SURFACES; RESOLUTION; ISOSTERE; EPOXIDES; MILD
National Category
Pharmaceutical Sciences Biochemistry and Molecular Biology
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URN: urn:nbn:se:uu:diva-51159DOI: 10.1016/S0040-4020(97)00482-1OAI: oai:DiVA.org:uu-51159DiVA: diva2:79068
Available from: 2006-03-04 Created: 2006-03-04 Last updated: 2017-12-04Bibliographically approved

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Danielson, Helena

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