Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor
1997 (English)In: Journal of Medicinal Chemistry, ISSN 0022-2623, E-ISSN 1520-4804, Vol. 40, no 6, 898-902 p.Article in journal (Refereed) Published
Two cyclic, C2-symmetric HIV-1 protease inhibitors, one sulfamide and one urea derivative, both comprising phenyl ether groups in the P1/P1‘ positions, were cocrystallized with HIV-1 protease, and the crystal structures were determined to 2.0 Å resolution. The structure of the urea 2 showed a conformation similar to that reported for the related urea 3 by Lam et al., while the sulfamide 1 adopted an unanticipated conformation in which the P1‘ and P2‘ side chains were transposed.
Place, publisher, year, edition, pages
1997. Vol. 40, no 6, 898-902 p.
IdentifiersURN: urn:nbn:se:uu:diva-51162DOI: 10.1021/jm960588dPubMedID: 9083478OAI: oai:DiVA.org:uu-51162DiVA: diva2:79071