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HIV-1 protease inhibitors based on acyclic carbohydrates
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1998 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 63, no 15, 4898-4906 p.Article in journal (Refereed) Published
Abstract [en]

A series of acyclic C2-symmetric HIV protease inhibitors readily accessible from D-mannitol have been developed. Several of the compounds synthesized showed significant in vitro activity against HIV-1 protease.

Place, publisher, year, edition, pages
1998. Vol. 63, no 15, 4898-4906 p.
Keyword [en]
HUMAN-IMMUNODEFICIENCY-VIRUS; BETA-D-GLUCOSE; D-MANNITOL; GLYCIDYL DERIVATIVES; VIRAL INFECTIVITY; AIDS; DRUGS; PEPTIDOMIMETICS; SYMMETRY; DESIGN
National Category
Pharmaceutical Sciences Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-51172DOI: 10.1021/jo971562cOAI: oai:DiVA.org:uu-51172DiVA: diva2:79081
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-04Bibliographically approved

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Publisher's full texthttp://pubs.acs.org/doi/pdf/10.1021/jo971562c

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Danielson, Helena

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Pharmaceutical SciencesMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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