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Does menopausal hormone therapy reduce myocardial infarction risk if initiated early after menopause?: A population-based case-control study
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2014 (English)In: Menopause: The Journal of the North American Menopause, ISSN 1072-3714, E-ISSN 1530-0374, Vol. 22, no 6, 598-606 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: This study aims to assess whether the timing of menopausal hormone therapy initiation in relation to onset of menopause and hormone therapy duration is associated with myocardial infarction risk.

METHODS: This study was based on the Stockholm Heart Epidemiology Program, a population-based case-control study including 347 postmenopausal women who had experienced a nonfatal myocardial infarction and 499 female control individuals matched for age and residential area. Odds ratios (with 95% CIs) for myocardial infarction were calculated using logistic regression.

RESULTS: Early initiation of hormone therapy (within 10 y of onset of menopause or before age 60 y), compared with never use, was associated with an odds ratio of 0.87 (95% CI, 0.58-1.30) after adjustments for lifestyle factors, body mass index, and socioeconomic status. For late initiation of hormone therapy, the corresponding odds ratio was 0.97 (95% CI, 0.53-1.76). For hormone therapy duration of 5 years or more, compared with never use, the adjusted odds ratio was 0.64 (95% CI, 0.35-1.18). For hormone therapy duration of less than 5 years, the odds ratio was 0.97 (95% CI, 0.63-1.48).

CONCLUSIONS: Neither the timing of hormone therapy initiation nor the duration of therapy is significantly associated with myocardial infarction risk.

Place, publisher, year, edition, pages
2014. Vol. 22, no 6, 598-606 p.
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Family Medicine
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URN: urn:nbn:se:uu:diva-245233DOI: 10.1097/GME.0000000000000354ISI: 000355238100005PubMedID: 25490112OAI: oai:DiVA.org:uu-245233DiVA: diva2:790846
Available from: 2015-02-26 Created: 2015-02-26 Last updated: 2017-12-04Bibliographically approved

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Hallqvist, Johan

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