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Does menopausal hormone therapy reduce myocardial infarction risk if initiated early after menopause?: A population-based case-control study
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2014 (English)In: Menopause: The Journal of the North American Menopause, ISSN 1072-3714, E-ISSN 1530-0374, Vol. 22, no 6, p. 598-606Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: This study aims to assess whether the timing of menopausal hormone therapy initiation in relation to onset of menopause and hormone therapy duration is associated with myocardial infarction risk.

METHODS: This study was based on the Stockholm Heart Epidemiology Program, a population-based case-control study including 347 postmenopausal women who had experienced a nonfatal myocardial infarction and 499 female control individuals matched for age and residential area. Odds ratios (with 95% CIs) for myocardial infarction were calculated using logistic regression.

RESULTS: Early initiation of hormone therapy (within 10 y of onset of menopause or before age 60 y), compared with never use, was associated with an odds ratio of 0.87 (95% CI, 0.58-1.30) after adjustments for lifestyle factors, body mass index, and socioeconomic status. For late initiation of hormone therapy, the corresponding odds ratio was 0.97 (95% CI, 0.53-1.76). For hormone therapy duration of 5 years or more, compared with never use, the adjusted odds ratio was 0.64 (95% CI, 0.35-1.18). For hormone therapy duration of less than 5 years, the odds ratio was 0.97 (95% CI, 0.63-1.48).

CONCLUSIONS: Neither the timing of hormone therapy initiation nor the duration of therapy is significantly associated with myocardial infarction risk.

Place, publisher, year, edition, pages
2014. Vol. 22, no 6, p. 598-606
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General Practice
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URN: urn:nbn:se:uu:diva-245233DOI: 10.1097/GME.0000000000000354ISI: 000355238100005PubMedID: 25490112OAI: oai:DiVA.org:uu-245233DiVA, id: diva2:790846
Available from: 2015-02-26 Created: 2015-02-26 Last updated: 2018-01-11Bibliographically approved

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Hallqvist, Johan

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