Alphitol, a phenolic substance from Alphitonia zizyphoides which inhibits prostaglandin biosynthesis in vitro
1998 (English)In: Phytochemistry, ISSN 0031-9422, E-ISSN 1873-3700, Vol. 48, no 3, 495-497 p.Article in journal (Refereed) Published
The new phenolic compound, 3,5-dihydroxy-4-methoxy phenethyl alcohol, named alphitol, and betulinic acid were isolated from the bark of Alphitonia zizyphoides. The chemical structure of alphitol was determined by mass spectrometry in combination with one and two dimensional NMR, including HMBC. Both compounds inhibited prostaglandin biosynthesis in vitro, alphitol with an IC50 value of 0.66 mM, which is of the same magnitude as acetyl salicylic acid.
Place, publisher, year, edition, pages
1998. Vol. 48, no 3, 495-497 p.
Alphitonia zizyphoides, Rhamnaceae, prostaglandin biosynthesis, phenyl ethanoid, alphitol, 3.5-dihydroxy-4-methoxy phenethyl alcohol, betulinic acid
IdentifiersURN: urn:nbn:se:uu:diva-51184DOI: 10.1016/S0031-9422(97)00827-3ISI: 000074422400017PubMedID: 9654777OAI: oai:DiVA.org:uu-51184DiVA: diva2:79093