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Alphitol, a phenolic substance from Alphitonia zizyphoides which inhibits prostaglandin biosynthesis in vitro
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
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1998 (English)In: Phytochemistry, ISSN 0031-9422, E-ISSN 1873-3700, Vol. 48, no 3, 495-497 p.Article in journal (Refereed) Published
Abstract [en]

The new phenolic compound, 3,5-dihydroxy-4-methoxy phenethyl alcohol, named alphitol, and betulinic acid were isolated from the bark of Alphitonia zizyphoides. The chemical structure of alphitol was determined by mass spectrometry in combination with one and two dimensional NMR, including HMBC. Both compounds inhibited prostaglandin biosynthesis in vitro, alphitol with an IC50 value of 0.66 mM, which is of the same magnitude as acetyl salicylic acid.

Place, publisher, year, edition, pages
1998. Vol. 48, no 3, 495-497 p.
Keyword [en]
Alphitonia zizyphoides, Rhamnaceae, prostaglandin biosynthesis, phenyl ethanoid, alphitol, 3.5-dihydroxy-4-methoxy phenethyl alcohol, betulinic acid
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-51184DOI: 10.1016/S0031-9422(97)00827-3ISI: 000074422400017PubMedID: 9654777OAI: oai:DiVA.org:uu-51184DiVA: diva2:79093
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-04Bibliographically approved

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