Preventive effects of ibuprofen on periarticular heterotopic ossification after total hip arthroplasty. A randomized double-blind prospective study of treatment time.
1998 (English)In: Acta Orthopaedica Scandinavica, ISSN 0001-6470, Vol. 69, no 2, 111-5 p.Article in journal (Refereed) Published
We determined the efficacy and the minimum treatment time necessary for prophylaxis with nonsteroidal anti-inflammatory drugs (NSAIDs) for periarticular heterotopic ossification (HO) after total hip arthroplasty (THA). Using a double-blind placebo controlled design, 144 patients operated on with total hip arthroplasty for primary arthrosis were treated postoperatively with (1) ibuprofen for 3 weeks, (2) ibuprofen for 1 week and placebo for the next 2 weeks or (3) placebo for 3 weeks. Radiographic occurrence of periarticular heterotopic ossification and complications of the treatment were recorded for the first year. Both ibuprofen-treated groups showed significantly less HO than the placebo-treated group. There was no difference in HO between the patients treated for 8 or 21 days postoperatively. Both 8 and 21 days of treatment with ibuprofen following THA effectively prevents clinically significant degrees of HO. No serious short-term complications of the treatment were noted.
Place, publisher, year, edition, pages
1998. Vol. 69, no 2, 111-5 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-245293PubMedID: 9602764OAI: oai:DiVA.org:uu-245293DiVA: diva2:791054