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Prevention of periarticular heterotopic ossification following total hip arthroplasty. Clinical experience with indomethacin and ibuprofen.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
1988 (English)In: Archives of orthopaedic and traumatic surgery. Archiv für orthopädische und Unfall-Chirurgie, ISSN 0344-8444, Vol. 107, no 6, 329-33 p.Article in journal (Refereed) Published
Abstract [en]

Prophylactic treatment with indomethacin or ibuprofen to prevent periarticular heterotopic ossification (PHO) was investigated in a consecutive series of 200 total hip replacements (THR) performed for primary coxarthrosis in 170 patients. No widespread PHO (grades III and IV) occurred in 166 THR treated with indomethacin or ibuprofen from the 1st to the 21st postoperative day. Only one patient exhibited moderate (grade-II) ossification. In contrast, the incidence of PHO grades III and IV was found to be high (23%) in the 35 THR for which the patients did not receive prophylaxis according to intention. It was concluded that 3 weeks' postoperative treatment with indomethacin or ibuprofen is sufficient to prevent the development of clinically significant heterotopic ossification.

Place, publisher, year, edition, pages
1988. Vol. 107, no 6, 329-33 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-245294PubMedID: 3149179OAI: oai:DiVA.org:uu-245294DiVA: diva2:791056
Available from: 2015-02-26 Created: 2015-02-26 Last updated: 2015-02-26

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