uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The locus C11orf30 increases susceptibility to poly-sensitization
Show others and affiliations
2015 (English)In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 70, no 3, 328-333 p.Article in journal (Refereed) Published
Abstract [en]

A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.

Place, publisher, year, edition, pages
2015. Vol. 70, no 3, 328-333 p.
National Category
Immunology in the medical area
URN: urn:nbn:se:uu:diva-245740DOI: 10.1111/all.12557ISI: 000349298100011PubMedID: 25546184OAI: oai:DiVA.org:uu-245740DiVA: diva2:791409
Available from: 2015-02-27 Created: 2015-02-27 Last updated: 2015-03-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Janson, Christer
By organisation
Respiratory Medicine and Allergology
In the same journal
Allergy. European Journal of Allergy and Clinical Immunology
Immunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 230 hits
ReferencesLink to record
Permanent link

Direct link