The locus C11orf30 increases susceptibility to poly-sensitization
2015 (English)In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 70, no 3, 328-333 p.Article in journal (Refereed) Published
A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.
Place, publisher, year, edition, pages
2015. Vol. 70, no 3, 328-333 p.
Immunology in the medical area
IdentifiersURN: urn:nbn:se:uu:diva-245740DOI: 10.1111/all.12557ISI: 000349298100011PubMedID: 25546184OAI: oai:DiVA.org:uu-245740DiVA: diva2:791409