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First cyclotide from Hybanthus (Violaceae)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
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2001 (English)In: Phytochemistry, ISSN 0031-9422, E-ISSN 1873-3700, Vol. 58, no 1, 47-51 p.Article in journal (Refereed) Published
Abstract [en]

Hypa A, a novel macrocyclic polypeptide containing 30 amino acid residues, has been isolated from the n-butanol extract of the Argentine plant Hybanthus parviflorus. The sequence, cyclo-(SCVYIPCTITALLGCSCKNKVCYNGIPCAE), was determined by automated Edman degradation, quantitative amino acid analysis and nanospray MS/MS2. Three intramolecular disulfide bridges stabilize the cyclic peptide backbone of hypa A. Using these structural features to classify the peptide as a cyclotide, we extended the distribution of that substance class to a new genus, and now propose a uniform nomenclature for cyclotides.

Place, publisher, year, edition, pages
Elsevier , 2001. Vol. 58, no 1, 47-51 p.
Keyword [en]
Hybanthus parviflorus (Mutis ex L. F.) Baill.; Violaceae; Violetilla; Isolation; Primary structure; Cyclotides; Macrocyclic polypeptides; Hypa A; LCQ
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-51280DOI: 10.1016/S0031-9422(01)00173-XOAI: oai:DiVA.org:uu-51280DiVA: diva2:79189
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-07-21Bibliographically approved

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