Rapid homogeneous-phase Sonogashira coupling reactions using controlled microwave heating
2001 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 66, no 12, 4165-4169 p.Article in journal (Refereed) Published
A microwave-enhanced, rapid and efficient homogeneous-phase version of the Sonogashira reaction is presented. It has been applied to the coupling of aryl iodides, bromides, triflates, and aryl chloride, as well as pyridine and thiophene derivatives with trimethylsilylacetylene. Excellent yields (80−95%) for substrates containing a large variety of substituents in different positions are obtained in 5−25 min.
Place, publisher, year, edition, pages
2001. Vol. 66, no 12, 4165-4169 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-51311DOI: 10.1021/jo0057250OAI: oai:DiVA.org:uu-51311DiVA: diva2:79220
Adresses: Gogoll A, Univ Uppsala, Inst Chem., Box 531, S-75121 Uppsala, Sweden2008-06-232008-06-232011-12-02Bibliographically approved