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Restoration of MPTP-induced deficits by exercise and Milmed (R) co-treatment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
2014 (English)In: PeerJ, ISSN 2167-8359, E-ISSN 2167-8359, Vol. 2, e531- p.Article in journal (Refereed) Published
Abstract [en]

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces permanent neurochemical and functional deficits. Following the administration of either two or four injections of the dopamine neurotoxin, MPTP, at a dose of 40 mg/kg, C57/BL6 mice were given access to running-wheels (30-min sessions, four times/week, Monday-Thursday) and treatment with the treated yeast, Milmed (R) (four times/week, Monday-Thursday), or simply running-wheel exercise by itself, over ten weeks. It was observed that the combination of physical exercise and Milmed (R) treatment, the MPTP + Exercise + Yeast (MC) group [MPTP + Exercise + Milmed (R) (MC)], restored spontaneous motor activity markedly by test day 10, restored completely subthreshold L-Dopa-induced activity, and dopamine concentration to 76% of control values, in the condition wherein two administrations of MPTP (2 x 40 mg/kg) were given prior to initiation of exercise and/or Milmed (R) treatment. Physical exercise by itself, MPTP + Exercise (MC) group, attenuated these deficits only partially. Administration of MPTP four times (i.e., 40 mg/kg, s.c., once weekly over four weeks for a total of 160 mg/kg, MPTP + Exercise + Yeast (MC) group [MPTP + Exercise + Milmed (R) (SC)] and MPTP + Exercise (SC), induced a lesioning effect that was far too severe for either exercise alone or the exercise + Milmed (R) combination to ameliorate. Nevertheless, these findings indicate a powerful effect of physical exercise reinforced by Milmed (R) treatment in restoring MPTP-induced deficits of motor function and dopamine neurochemistry in mice.

Place, publisher, year, edition, pages
2014. Vol. 2, e531- p.
Keyword [en]
MPTP, Exercise, Milmed (R), Parkinsonism, Running-wheels, Locomotion, Total activity, Dopamine, Attenuation, Restoration
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-244600DOI: 10.7717/peerj.531ISI: 000347618300003PubMedID: 25210657OAI: oai:DiVA.org:uu-244600DiVA: diva2:793344
Available from: 2015-03-06 Created: 2015-02-18 Last updated: 2017-12-04Bibliographically approved

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Fredriksson, Anders

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