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A genome-wide association study of marginal zone lymphoma shows association to the HLA region
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2015 (English)In: Nature Communications, ISSN 2041-1723, Vol. 6, UNSP 5751Article in journal (Refereed) Published
Abstract [en]

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

Place, publisher, year, edition, pages
2015. Vol. 6, UNSP 5751
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-245523DOI: 10.1038/ncomms6751ISI: 000348646500001PubMedID: 25569183OAI: oai:DiVA.org:uu-245523DiVA: diva2:793990
Available from: 2015-03-10 Created: 2015-02-26 Last updated: 2015-03-10Bibliographically approved

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