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A prognosis based classification of undifferentiated uterine sarcomas: Identification of mitotic index, hormone receptors and YWHAE-FAM22 translocation status as predictors of survival
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
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2015 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 136, no 7, 1608-1618 p.Article in journal (Refereed) Published
Abstract [en]

Undifferentiated uterine sarcomas (UUS) are rare tumors with a heterologous biology and a poor prognosis. The goal of this study was to examine clinicopathology, biomarkers and YWHAE-FAM22 translocation status, in the prognosis of these tumors. Twenty-six cases of UUS were included. All original slides were rereviewed and age at diagnosis, tumor stage, Kurihara diagnosis, mitotic index, presence of necrosis and grade of nuclear atypia were recorded. Additionally, a tissue microarray was constructed from 22 of the cases, and the protein biomarkers P53, P16, Ki-67, Cyclin-D1, ER, PR and ANLN were evaluated by immunohistochemistry. All tumors were evaluated for the presence of a YWHAE-FAM translocation; the translocation was demonstrated in the three Cyclin-D1 positive tumors. Follow-up data in the form of overall survival were available on all patients. These tumors could be divided into two prognostic groups, a high mitotic index group (10 cases, M=36.8, SD=5.4) and a low mitotic index group (16 cases, M=8.7, SD=5.8). These two groups showed a statistically significant difference in prognosis. The expression of ER, PR or presence of the YWHAE-FAM22 translocation correlated with low mitotic index and an additionally improved prognosis, although the number of cases was small. These results indicate that UUS can be divided into two prognostic groups using mitotic index as a primary criteria, followed by expression of either ER, PR or the presence of a YWHAE-FAM22 translocation as a secondary criteria. This study demonstrates the presence of statistically significant prognostic subgroups within UUS, and provides treatment insights.

Place, publisher, year, edition, pages
2015. Vol. 136, no 7, 1608-1618 p.
Keyword [en]
endometrial stromal sarcoma, undifferentiated uterine sarcoma, prognosis, biomarkers
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-246326DOI: 10.1002/ijc.29141ISI: 000348443400014PubMedID: 25130488OAI: oai:DiVA.org:uu-246326DiVA: diva2:794151
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De två första författarna delar förstaförfattarskapet.

Available from: 2015-03-10 Created: 2015-03-05 Last updated: 2017-12-04Bibliographically approved

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Pontén, Fredrik

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Department of Immunology, Genetics and PathologyScience for Life Laboratory, SciLifeLabMolecular and Morphological Pathology
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