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Dead space during one-lung ventilation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Hedenstierna laboratory.
2015 (English)In: Current Opinion in Anaesthesiology, ISSN 0952-7907, E-ISSN 1473-6500, Vol. 28, no 1, 10-17 p.Article, review/survey (Refereed) Published
Abstract [en]

Purpose of review Describe the importance of monitoring dead space during thoracic surgery, specifically during one-lung ventilation. Recent findings The concept of dead space has gained renewed interest among anesthesiologists ever since breath-by-breath measurement by volumetric capnography became available. Monitoring dead space during thoracic surgery assesses the ventilatory deficiencies related to increases in instrumental, airway and/or alveolar dead space, when ventilating patients with positive pressure and double-lumen tubes. Another interesting use of such monitoring is to detect ventilator-induced lung injury due to tidal overdistension. This type of injury threatens the fragile lungs especially during one-lung ventilation and can clinically be recognized as an increase in airway and alveolar dead space above normal values. To date, lung protective ventilation is based on the use of low tidal volumes and airway pressures to decrease overdistension. It has been shown to reduce the incidence of postoperative pulmonary complications after thoracic surgeries. However, such a ventilatory strategy impairs ventilation and induces hypercapnia due to increases in dead space. Therefore, continuous assessment of dead space is helpful in guiding ventilation and avoiding overdistension while maintaining the elimination of CO2 during thoracic surgery sufficiently high. Summary Monitoring dead space helps anesthesiologists monitor the status of the lung and find appropriate ventilatory settings during thoracic surgeries.

Place, publisher, year, edition, pages
2015. Vol. 28, no 1, 10-17 p.
Keyword [en]
atelectasis, dead space, lung injury, lung recruitment, one-lung ventilation, positive end-expiratory pressure
National Category
Anesthesiology and Intensive Care
URN: urn:nbn:se:uu:diva-246834DOI: 10.1097/ACO.0000000000000153ISI: 000347394200004PubMedID: 25517622OAI: oai:DiVA.org:uu-246834DiVA: diva2:794314
Available from: 2015-03-11 Created: 2015-03-10 Last updated: 2015-03-11Bibliographically approved

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Suarez-Sipmann, Fernando
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