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The mitotic checkpoint protein kinase BUB1 is an engine in the TGF-beta signaling apparatus
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
2015 (English)In: Science Signaling, ISSN 1945-0877, E-ISSN 1937-9145, Vol. 8, no 359, fs1Article in journal, Editorial material (Other academic) Published
Abstract [en]

The transforming growth factor-beta (TGF-beta) pathway mediates critical events in cell behavior that contribute to development and disease. The mitotic checkpoint guarantees faithful chromosomal segregation during cell division. In the 6 January 2015 issue of Science Signaling, Nyati et al. reported that the mitotic checkpoint kinase BUB1 promotes the activity of TGF-beta receptors, which adds new molecular links between these fundamental biological processes.

Place, publisher, year, edition, pages
2015. Vol. 8, no 359, fs1
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:uu:diva-246862DOI: 10.1126/scisignal.aaa4636ISI: 000347920200001OAI: oai:DiVA.org:uu-246862DiVA: diva2:794512
Available from: 2015-03-11 Created: 2015-03-11 Last updated: 2017-12-04Bibliographically approved

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Moustakas, Aristidis

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