N-Methyl-D-Aspartate Receptor Autoimmunity Affects Cognitive Performance in Herpes Simplex Encephalitis
(English)Manuscript (preprint) (Other academic)
Herpes simplex encephalitis (HSE) is the most common cause of sporadic viral encephalitis. It has previously been suggested that autoimmune reactions involving the N-methyl-D-aspartate receptor (NMDAR) could complicate recovery after HSE, and specific antibodies have been found in cases of clinical relapse. In this study, we investigate the prevalence and temporal development of anti-NMDAR IgG in patients with HSE and evaluate their neurocognitive recovery during 2 years after infection. Antibodies were found in 11 of 47 patients, and in 9 of 11 positive cases the antibodies were detectable only after 3 months of follow-up. Furthermore, the antibody positive subjects presented with an impaired recovery of neurocognitive performance compared to antibody negative subjects. We believe that this is the first study to show the clinical impact of this autoimmune mechanism in HSE.
Research subject Medical Science
IdentifiersURN: urn:nbn:se:uu:diva-246376OAI: oai:DiVA.org:uu-246376DiVA: diva2:795201