Silent coeliac disease is over-represented in children with type 1 diabetes and their siblings
2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no 2, 185-191 p.Article in journal (Refereed) Published
AimThis study measured autoantibodies against tissue transglutaminase (anti-tTG) to detect untreated coeliac disease in children with type 1 diabetes and their siblings. MethodsAnti-tTG was measured in prospectively collected sera from 169 children at the onset of diabetes, 88 of their siblings and 96 matched control children. Coeliac disease was confirmed with a small intestinal biopsy. ResultsCoeliac disease was diagnosed in five children before diabetes onset. A further 12 children were diagnosed after diabetes onset, without any gastrointestinal symptoms, and 11 of these had anti-tTG at the onset of diabetes, with the remaining child showing seroconversion within 6months. Hence, all the children with both diseases had anti-tTG at or before diabetes diagnosis, and the prevalence of coeliac disease was 10.1%. Moreover, 6.8% of the siblings and 3.1% of the control children had elevated levels of anti-tTG. None of the siblings reported any coeliac-related symptoms, despite being positive for anti-tTG, and coeliac disease has so far been biopsy confirmed in 4.5%. ConclusionSilent coeliac disease is over-represented in children with type 1 diabetes and their siblings. All diabetes children and their siblings should be tested and followed for the presence of anti-tTG and coeliac disease.
Place, publisher, year, edition, pages
2015. Vol. 104, no 2, 185-191 p.
Autoantibodies, Coeliac disease, tissue transglutaminase, Type 1 diabetes
Pediatrics Endocrinology and Diabetes
IdentifiersURN: urn:nbn:se:uu:diva-246809DOI: 10.1111/apa.12823ISI: 000348731000024PubMedID: 25283799OAI: oai:DiVA.org:uu-246809DiVA: diva2:795385