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Tissue-based map of the human proteome
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
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2015 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 347, no 6220, 394-+ p.Article in journal (Refereed) Published
Abstract [en]

Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.

Place, publisher, year, edition, pages
2015. Vol. 347, no 6220, 394-+ p.
National Category
Biological Sciences Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
URN: urn:nbn:se:uu:diva-247157DOI: 10.1126/science.1260419ISI: 000348225800036OAI: oai:DiVA.org:uu-247157DiVA: diva2:795540
Available from: 2015-03-16 Created: 2015-03-13 Last updated: 2015-11-06Bibliographically approved

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Lindskog, CeciliaKampf, CarolineSjöstedt, EvelinaAsplund, AnnaOlsson, IngMarieDjureinovic, DijanaEdqvist, Per-HenrikPontén, Fredrik
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Science for Life Laboratory, SciLifeLabDepartment of Immunology, Genetics and PathologyMolecular and Morphological Pathology
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Biological SciencesMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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