Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia
2015 (English)In: Journal of Cystic Fibrosis, ISSN 1569-1993, E-ISSN 1873-5010, Vol. 14, no 1, 46-52 p.Article in journal (Refereed) Published
Background: Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described. Methods: In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from 2000 to the end of 2012 and used national CF databases to describe microbiological and clinical characteristics. Results: During the 13-year period 157 (11%) CF patients were culture positive for NTM at least once. Mycobacterium abscessus complex (MABSC) (45%) and Mycobacterium avium complex (MAC) (32%) were the predominant species with geographical differences in distribution. Younger patients were more prone to MABSC (p < 0.01). Despite treatment, less than one-third of MABSC patients with repeated positive cultures cleared their infection and a quarter had a lung transplant or died. Conclusion: NTM are significant CF pathogens and are becoming. more prevalent in Scandinavia. MABSC and MAC appear to target distinct patient groups. Having multiple positive cultures despite treatment conveys a poor outcome. (C) 2014 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.
Place, publisher, year, edition, pages
2015. Vol. 14, no 1, 46-52 p.
Mycobacterium abscessus, Mycobacterium avium, Prevalence, Susceptibility
Respiratory Medicine and Allergy
IdentifiersURN: urn:nbn:se:uu:diva-247324DOI: 10.1016/j.jcf.2014.08.002ISI: 000348747700007PubMedID: 25178871OAI: oai:DiVA.org:uu-247324DiVA: diva2:796967