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Antibodies as Natural Adjuvants
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2014 (English)In: FC RECEPTORS, 2014, 201-219 p.Chapter in book (Refereed)
Abstract [en]

Antibodies in complex with specific antigen can dramatically change the antibody response to this antigen. Depending on antibody class and type of antigen, >99 % suppression or >100-fold enhancement of the response can take place. IgM and IgG3 are efficient enhancers and operate via the complement system. In contrast, IgG1, IgG2a, and IgG2b enhance antibody and CD4(+) T cell responses to protein antigens via activating Fc gamma-receptors. IgE also enhances antibody and CD4(+) T cell responses to small proteins but uses the low-affinity receptor for IgE, CD23. Most likely, IgM and IgG3 work by increasing the effective concentration of antigen on follicular dendritic cells in splenic follicles. IgG1, IgG2a, IgG2b, and IgE probably enhance antibody responses by increasing antigen presentation by dendritic cells to T helper cells. IgG antibodies of all subclasses have a dual effect, and suppress antibody responses to particulate antigens such as erythrocytes. This capacity is used in the clinic to prevent immunization of Rhesus-negative women to Rhesus-positive fetal erythrocytes acquired via transplacental hemorrage. IgG-mediated suppression in mouse models can take place in the absence of Fc gamma-receptors and complement and to date no knock-out mouse strain has been found where suppression is abrogated.

Place, publisher, year, edition, pages
2014. 201-219 p.
, Current Topics in Microbiology and Immunology, ISSN 0070-217X ; 382
National Category
Microbiology in the medical area Immunology in the medical area
URN: urn:nbn:se:uu:diva-247741DOI: 10.1007/978-3-319-07911-0_9ISI: 000348980000010PubMedID: 25116101ISBN: 978-3-319-07911-0ISBN: 978-3-319-07910-3OAI: oai:DiVA.org:uu-247741DiVA: diva2:797258
Available from: 2015-03-23 Created: 2015-03-23 Last updated: 2015-03-23Bibliographically approved

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Heyman, Birgitta
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Department of Medical Biochemistry and Microbiology
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