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Karyotype variability in Trypanosoma cruzi
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology. (Genome Analysis)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology, Medical Genetics. (Genome Analysis)
1996 (English)In: Parasitology Today, ISSN 0169-4758, E-ISSN 1873-1473, Vol. 12, no 3, 108-114 p.Article in journal (Refereed) Published
Abstract [en]

Like many other protozoam parasites, Trypanosoma cruzi (the causative agent of Chagas disease) has a plastic genome. Chromosome size polymorphisms occur in different strains of T. cruzi as well as among clones originating from the same strain, Despite this polymorphism, major interchromosomal rearrangements appear to be rare since several linkage groups of chromosomal markers are well conserved among different T. cruzi strains. In addition, some correlation has been found between karyotype variability and classification by multilocus enzyme electrophoresis. In this review, Jan Henriksson, Lena Åslund and Ulf Petterson discuss the genomic variability and suggest that amplication of repetitive sequences or members of gene families make a major contribution to the chromosomal size variation

Place, publisher, year, edition, pages
1996. Vol. 12, no 3, 108-114 p.
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:uu:diva-51967DOI: 10.1016/0169-4758(96)80670-3PubMedID: 15275240OAI: oai:DiVA.org:uu-51967DiVA: diva2:79876
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-04Bibliographically approved

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