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Splenic marginal-zone lymphoma: ontogeny and genetics
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
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2015 (English)In: Leukemia and Lymphoma, ISSN 1042-8194, Vol. 56, no 2, 301-310 p.Article, review/survey (Refereed) Published
Abstract [en]

Splenic marginal-zone lymphoma (SMZL) is a rare tumor that has recently emerged as a prototype for how the interplay between genetics and environment shapes the natural history of lymphomas. Indeed, the recent identification of molecular immunogenetic subgroups within SMZL may prove to be relevant not only for the sub-classification of the disease but also for improved understanding of the underlying biology. In contrast to other B-cell lymphomas, SMZL lacks a characteristic genetic lesion, although the majority of cases harbor genomic aberrations, as recently revealed by high-throughput studies that identified recurrent genetic aberrations, several in pathways related to marginal-zone differentiation and B-cell signaling. Here we provide an overview of recent research into the molecular and cellular biology of SMZL and related disorders, with special emphasis on immunogenetics and genomic aberrations, and discuss the value of molecular and cellular markers for the diagnosis and differential diagnosis of these entities.

Place, publisher, year, edition, pages
2015. Vol. 56, no 2, 301-310 p.
Keyword [en]
Lymphoma and Hodgkin disease, cytogenetics, molecular genetics
National Category
Cancer and Oncology Hematology
URN: urn:nbn:se:uu:diva-247834DOI: 10.3109/10428194.2014.919636ISI: 000349662000008PubMedID: 24798744OAI: oai:DiVA.org:uu-247834DiVA: diva2:799180
Available from: 2015-03-30 Created: 2015-03-24 Last updated: 2015-03-30Bibliographically approved

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Baliakas, Panagiotis
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Science for Life Laboratory, SciLifeLabExperimental and Clinical OncologyDepartment of Immunology, Genetics and Pathology
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