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Interleukin-8 is associated with increased total mortality in women but not in men-findings from a community-based cohort of elderly
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
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2015 (English)In: Annals of Medicine, ISSN 0785-3890, E-ISSN 1365-2060, Vol. 47, no 1, 28-33 p.Article in journal (Refereed) Published
Abstract [en]

Objective. To elucidate the association among circulating IL-8 and total mortality in a cohort of elderly, and to explore potential sex differences in the observed association. Methods. The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) is a cohort of 70-year-old men and women living in Uppsala, Sweden; baseline period: 2001-2004. IL-8 serum measurements were performed in 1003 participants. Results. In total, 61 men and 40 women died during follow-up (median 7.9 years). Baseline IL-8 concentrations were higher in women than in men (P = 0.03). In a multivariable model adjusting for age, established cardiovascular risk factors, and C-reactive protein, log-transformed standard deviation increments in IL-8 levels were weakly associated with an increased risk for total mortality (hazard ratio (HR) 1.12, 95% confidence interval (CI) 1.02 -1.23, P < 0.05) in the whole cohort. Stratified analysis revealed an association in women (HR 1.18, 95% CI 1.06-1.30, P < 0.01) but not in men (HR 0.98, 95% CI 0.76-1.26). Conclusions. A weak association between IL-8 serum levels and an increased risk for mortality was observed. The prospective data support the role of IL-8 as a biomarker of interest; yet, further studies are warranted to elucidate validity of our finding and the possibility of a sex difference.

Place, publisher, year, edition, pages
2015. Vol. 47, no 1, 28-33 p.
Keyword [en]
All-cause mortality, community-based cohort, cytokines, inflammation, interleukin-8
National Category
Other Medical Sciences
URN: urn:nbn:se:uu:diva-248464DOI: 10.3109/07853890.2014.962596ISI: 000349978400004OAI: oai:DiVA.org:uu-248464DiVA: diva2:799631
Available from: 2015-03-31 Created: 2015-03-30 Last updated: 2015-03-31Bibliographically approved

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Ärnlöv, JohanLind, Lars
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