Mild Microwave-Assisted Synthesis of Dipyrromethanes and Their Analogues
2015 (English)In: Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, ISSN 0936-5214, E-ISSN 1437-2096, Vol. 26, no 4, 484-488 p.Article in journal (Refereed) Published
The Mannich reaction between pyrroles or indoles and Eschenmoser's salt (dimethylmethylideneammonium iodide) forms N,N-dimethylamino-methylated derivatives in good to excellent yields. The reaction is highly regioselective, and for pyrroles both 2- and 3-substituted derivatives could be obtained. The N,N-dimethylaminomethylpyrroles and indoles underwent substitution with pyrrole under microwave irradiation, affording the appropriate dipyrromethanes, N-confused, and indolo-dipyrromethanes in moderate to excellent overall yield.
Place, publisher, year, edition, pages
2015. Vol. 26, no 4, 484-488 p.
pyrroles, indoles, heterocycles, microwave synthesis, dipyrromethanes
Other Chemistry Topics
IdentifiersURN: urn:nbn:se:uu:diva-248448DOI: 10.1055/s-0034-1378925ISI: 000350059200010OAI: oai:DiVA.org:uu-248448DiVA: diva2:800284