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Next-Generation Sequencing Reveals a Controlled Immune Response to Zaire Ebola Virus Challenge in Cynomolgus Macaques Immunized with Vesicular Stomatitis Virus Expressing Zaire Ebola Virus Glycoprotein (VSV Delta G/EBOVgp)
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational and Systems Biology.
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2015 (English)In: Clinical and Laboratory Immunology, ISSN 1556-6811, E-ISSN 1556-679X, Vol. 22, no 3, 354-356 p.Article in journal (Refereed) Published
Abstract [en]

Vesicular stomatitis virus expressing Zaire Ebola virus (EBOV) glycoprotein (VSV Delta G/EBOVgp) could be used as a vaccine to meet the 2014 Ebola virus outbreak. To characterize the host response to this vaccine, we used mRNA sequencing to analyze peripheral blood mononuclear cells (PBMCs) from cynomolgus macaques after VSV Delta G/EBOVgp immunization and subsequent EBOV challenge. We found a controlled transcriptional response that transitioned to immune regulation as the EBOV was cleared. This observation supports the safety of the vaccine.

Place, publisher, year, edition, pages
2015. Vol. 22, no 3, 354-356 p.
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URN: urn:nbn:se:uu:diva-248815DOI: 10.1128/CVI.00733-14ISI: 000350333700015PubMedID: 25589554OAI: oai:DiVA.org:uu-248815DiVA: diva2:801442
Available from: 2015-04-09 Created: 2015-04-08 Last updated: 2015-04-09Bibliographically approved

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Barrenäs, Fredrik
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