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Enhanced splicing of nonconsensus 3' splice sites late during adenovirus infection
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
1995 (English)In: Journal of Virology, ISSN 0022-538X, E-ISSN 1098-5514, Vol. 69, no 11, 7324-7327 p.Article in journal (Refereed) Published
Abstract [en]

The adenovirus major late transcription unit is an example of an alternatively spliced gene, in which a common 5' splice site can be spliced to more than 15 different 3' splice sites. Here we show that the specificity in 3' splice site recognition changes during virus infection, such that 3' splice sites with long consensus-type polypyrimidine tracts are repressed while 3' splice sites with short atypical polypyrimidine tracts, which bind U2AF65K inefficiently, are enhanced in splicing in late virus-infected nuclear extracts. On the basis of these experiments, we discuss a mechanism that helps to explain how the complex pattern of major late mRNAs is produced late during virus infection.

Place, publisher, year, edition, pages
1995. Vol. 69, no 11, 7324-7327 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-52572ISI: A1995RZ10000095PubMedID: 7474163OAI: oai:DiVA.org:uu-52572DiVA: diva2:80482
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-04Bibliographically approved

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